Plasma miR-323 as a Biomarker for Screening Papillary Thyroid Cancer From Healthy Controls

Plasma miR-323 as a Biomarker for Screening Papillary Thyroid Cancer From Healthy Controls

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The present study aims to evaluate whether plasma here miR-323 serves as a potential biomarker to screen patients with papillary thyroid cancer (PTC) from healthy controls.Real-time PCR was performed to evaluate miR-323 expression in healthy controls and benign thyroid nodule (BTN) and PTC patients.Receiver operating characteristic (ROC) curve analysis was used to evaluate whether plasma miR-323 could be used to screen PTC patients from BTN patients and healthy controls.

Plasma miR-323 was significantly increased in PTC patients compared with that in BNT patients and healthy controls.Moreover, miR-323 in the thyroid tissue was significantly increased in PTC patients when compared to BNT patients.We further showed that plasma and tissue miR-323 levels were significantly increased in PTC patients with metastasis compared to those without metastasis.

Plasma iphone 14 price texas miR-323 was significantly increased in PTC patients with BRAF V600E mutation when compared to those with wild-type BRAF.Furthermore, plasma miR-323 was significantly increased in PTC patients with higher Tg-FNAB.ROC analysis showed that plasma miR-323 could distinguish PTC patients from BNT patients and healthy controls.

The present study demonstrated that plasma miR-323 might be an effective noninvasive indicator for PTC progression and serve as a biomarker for the diagnosis of PTC.